Endocrine Abstracts

The patients following craniospinal irradiation (CSI) in young ages due to posterior fossa tumors had high risk of hypopituitarism. The glucagon stimulation test (GST) may be used as alternative the insulin tolerance test (ITT) in the diagnosis of GH deficiency (GHD) and central adrenal insufficiency (CAI) when insulin-induced hypoglycaemia is contraindicated e.g. history of convulsions, coronary heart disease, also it can be carry out as an outpatient. The aim of this study w...

The glucagon stimulation test (GST) may be used as a good alternative to the insulin tolerance test (ITT) in the diagnosis of secondary adrenal insufficiency (SAI). The aim of the study was to compare the GST and ITT for diagnostic SAI, to define cortisol cut-off points and factors affecting the appearance of false positive results in young adults followed CSI.Subjects and Methods: A retrospective study of 28 patients (median age 19 [17; 23]) at least 2 ...

Abstract: The secondary adrenal insufficiency (SAI) is life-threatening disease. 30–50% of patients have SAI following craniospinal irradiation (CSI). The “gold standard” of SAI diagnosis is the insulin tolerance test but it is demanding for patient and medical staff. The simple and reliable test would allow to use ITT rarely. The aim was to evaluate probability of using DHEA-S in SAI diagnosis. 41 patient after CSI non-pituitary brain tumors survivor and 23 hea...

The number of the non-pituitary brain tumors survives increases and will be growing up in the future. Although the prevalence of secondary adrenal insufficiency (SAI) vary depending on the methods of diagnostic, we have a few data about their ACTH and DHAE-S status. The aim of our study was to describe the hypotalamic-pituitary-adrenal axis (HPAA) changes after craniospinal irradiation (CRT) and diagnostic utility basal cortisol (BC), DHAE-S, glucagon stimulation test (GST) in...